3-Hydroxybenzoic acid
3-Hydroxybenzoic acid
CAS: 99-06-9
Molecular Formula: C7H6O3
3-Hydroxybenzoic acid - Names and Identifiers
3-Hydroxybenzoic acid - Physico-chemical Properties
| Molecular Formula | C7H6O3 |
| Molar Mass | 138.12 |
| Density | 1.4850 |
| Melting Point | 200-203 °C (lit.) |
| Boling Point | 213.5°C (rough estimate) |
| Flash Point | 220 °C |
| Water Solubility | slightly soluble |
| Solubility | Soluble in hot water, soluble in ethanol and ether, slightly soluble in cold water, insoluble in benzene. |
| Vapor Presure | 2.24E-05mmHg at 25°C |
| Appearance | White crystal |
| Color | White to off-white |
| BRN | 508160 |
| pKa | 4.06(at 19℃) |
| PH | 3 (H2O)Aqueous solution |
| Storage Condition | 置于干燥的库房内，远离火源。 |
| Sensitive | Sensitive to light |
| Refractive Index | 1.4600 (estimate) |
| MDL | MFCD00002506 |
| Physical and Chemical Properties | Appearance colorless crystals solubility slightly soluble in water and benzene, soluble in ethanol and n-butanol |
| Use | Used in the preparation of herbicides, fungicides, preservatives, ion exchangers, plasticizers and pharmaceutical intermediates, can also be used to synthesize azo dyes |
| Caution | Corrosive, pay attention to protection. Splash onto the skin and rinse with plenty of soapy water. |
3-Hydroxybenzoic acid - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | DH1924980 |
| TSCA | Yes |
| HS Code | 29182990 |
| Hazard Note | Irritant |
3-Hydroxybenzoic acid - Reference
| Reference Show more | 1. [IF=4.235] Dong Qingying et al."High Oxygen Treatments Enhance the Contents of Phenolic Compound and Ganoderic Acid, and the Antioxidant and DNA Damage Protective Activities of Ganoderma lingzhi Fruiting Body."Front Microbiol. 2019 Oct;0:2363 2. [IF=4.952] Yulong Wei et al."Characterization of blueberry (Vaccinium corymbosum L.) catechol oxidases III binding mechanism in response to selected substrates and inhibitors."Lwt Food Sci Technol. 2022 Mar;158:113142 |
3-Hydroxybenzoic acid - Nature
Open Data Verified Data
White needle-like crystals. Soluble in hot water. Soluble in alcohol, ether, slightly soluble in cold water, insoluble in benzene. Flammable in case of open flame and high heat. By high heat decomposition, emission of irritating smoke. Stable nature, can occur hydroxyl and carbonyl reaction. It is incompatible with oxidant, fluorine and lead acetate.
Last Update：2024-01-02 23:10:35
3-Hydroxybenzoic acid - Introduction
Median lethal dose (rat, abdominal cavity) 3700mg/kg. It's irritating.
Last Update：2022-10-16 17:30:31
3-Hydroxybenzoic acid - Preparation method
Open Data Verified Data
Put 122kg of benzoic acid into the reactor and add 100kg of fuming sulfuric acid while stirring. Heat up to about 100 ℃ and react for about 2 hours to obtain meta carboxybenzenesulfonic acid. Then transfer the sulfonation solution to an alkali melting pot, add 45kg of solid sodium hydroxide, heat up to melting, and react for 4-5 hours to obtain sodium carboxyphenol. Add dilute sulfuric acid for acidic hydrolysis. Cool and crystallize, filter out sodium sulfate, and decolorize the filter cake with activated carbon to obtain the finished product.
Last Update：2023-12-08 11:09:53
3-Hydroxybenzoic acid - Safety
Open Data Verified Data
mouse oral LD50:2000mg/kg. In general, no significant risk of exposure, vapor on the upper respiratory tract, eyes and skin irritation. Staff should be protected. If the skin and eyes are touched, they should be immediately rinsed with flowing water. It is harmful to the environment and can cause pollution to water and atmosphere. Avoid contact with oxidants and alkalis. Store in a cool, ventilated warehouse. Keep away from fire and heat source. Keep the container sealed. Should be stored separately from the oxidant, alkali.
Last Update：2022-01-01 09:30:48
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